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Figure 3 | Molecular Pain

Figure 3

From: Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia

Figure 3

Long-term potentiation (LTP) and long-term depression (LTD) in ACC slices of wild-type and αCaMKII-F89G transgenic mice. A. Model for the design of αCaMKII-F89G transgenic mice and the selective chemical inhibitor. B. Prolonged low frequency stimulation (1 Hz for 15 min) induced LTD of synaptic responses in the ACC of wild-type mice. However, LTD was abolished in slices of αCaMKII-F89G transgenic mice. Inset: traces of field EPSPs recorded before (Pre) and after [22] LTD induction in wild-type and αCaMKII-F89G transgenic mice. C. Similar LTP was induced by theta burst stimulation (TBS) in ACC slices of wild-type and αCaMKII-F89G transgenic mice. D. Summarized results of frequency-dependent responses in wild-type and αCaMKII-F89G transgenic mice. The average field EPSPs (% of control) of last 5 min recording (40–45 min in A) were used for the plot. * P < 0.05 significantly different from wild-type mice.

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Molecular Pain

ISSN: 1744-8069

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