Behavioral nociceptive responses to noxious heat, mechanical pressure and formalin injection were not altered in αCaMKII-F89G transgenic mice. A-B. Behavioral nociceptive responses to noxious heating in the tail-flick test at two different heating intensities (A) and the hot-plate test at three different temperatures (50, 52, 55°C) (B). No significant differences were found between wild-type and αCaMKII-F89G transgenic mice in any test. C-D. No significant differences were found in hind paw withdrawal responses to noxious heating or mechanical pressure. E. Behavioral nociceptive responses to hindpaw formalin injection, plotted in 5-min intervals, in wild type mice as compared to αCaMKII-F89G transgenic mice. No significant difference was found between wild-type and transgenic mice.