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Figure 6 | Molecular Pain

Figure 6

From: Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia

Figure 6

Reduction in allodynia and hyperalgesia can be reversed by inhibiting the overexpression of CaMKII activity in αCaMKII-F89G transgenic mice. A. One-week pretreatment with the inhibitor 1NM-PP1 reversed the reduction of behavioral allodynia in αCaMKII-F89G transgenic mice. No significant difference was found between wild-type mice and αCaMKII-F89G transgenic mice receiving 1NM-PP1 pretreatment. B. One-week pretreatment with 1NM-PP1 reversed the reduction of behavioral hyperalgesia in αCaMKII-F89G transgenic mice. No significant difference was found between wild-type mice and αCaMKII-F89G transgenic mice receiving 1NM-PP1 pretreatment.

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Molecular Pain

ISSN: 1744-8069

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