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Figure 7 | Molecular Pain

Figure 7

From: Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia

Figure 7

'Rescued' LTD in αCaMKII-F89G transgenic mice by inhibiting the overexpression of CaMKII activity in αCaMKII-F89G transgenic mice. A. One-week pretreatment with 1NM-PP1 reversed the reduction of cingulate LTD in αCaMKII-F89G transgenic mice. For comparison, the same plot of αCaMKII-F89G transgenic mice shown in Figure 3 was used. B. Summarized data for LTD in wild-type, αCaMKII-F89G transgenic mice, and αCaMKII-F89G transgenic mice with 1NM-PP1 pretreatment. The average field EPSPs (% of control) of last 5 min recording (40–45 min in A) were used for the plot. * P < 0.05 as compared with αCaMKII-F89G transgenic mice.

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