Effect of fostriecin infusion (3 μM; n = 10) or ACSF (n = 12) on increased activity of nociceptive dorsal horn neurons induced by capsaicin (0.1%, 10 μl) injection (arrows). Fostriecin or ACSF was continuously infused for 30 minutes before capsaicin injection (upper horizontal bars). The value before drug infusion was recorded as baseline. (A) Background acitivity; (B) Response to brush stimulus; (C) Response to press; (D) Response to pinch. ●○, P < 0.05, significant difference from baseline in each different lines. All values are presented as mean ± SEM.