Figure 1

Lack of nerve injury- and LPA-induced reduction of spinal SP immunoreactivity in LPA ₁ ^-/- mice and mice with BoNT/C3 treatment. (A) Loss of nerve injury-induced reduction of SP immunoreacctivity in LPA₁ ^-/- mice and mice with BoNT/C3 pretreatment (10 pg, 1 hr prior to injury). (B) Loss of LPA (1 nmol, i.t.)-induced reduction of SP immunoreacctivity in LPA₁ ^-/- mice and mice with BoNT/C3 pretreatment. (C, D) Quantification of SP immunoreactivity in nerve injured mice (C) or in LPA-treated mice (D). Data are presented as means ± S.E.M. from experiments using at least 3 mice.