Skip to main content
Figure 5 | Molecular Pain

Figure 5

From: Ionic basis of a mechanotransduction current in adult rat dorsal root ganglion neurons

Figure 5

The mechanotransduction current can be carried by organic ions. (A) Mechanically activated current traces recorded from a DRG neuron (48-μm diameter) when bath solution consisted of 140 mM choline chloride at membrane voltages stepped from -111 to +89 mV in increments of 40 mV. (B) Mean current-voltage relation in choline chloride bath (closed circles). The mean amplitude of current seen in standard solutions at -70 mV, in the same cells using the same stimulus parameters, is indicated by the open circle. (C) Current traces recorded from a 35-μm neuron when bathed in 140 mM NMDG-Cl with membrane voltage clamped at -112 to +88 mV in increments of 40 mV. Probe velocity was 3.9 mm/s. (D) Mean current-voltage relation for mechanotransduction currents in N-mtheyl-D-glucamine chloride bath (closed circles). The mean amplitude of current seen in standard solutions at -70 mV, in the same cells using the same stimulus parameters, is indicated by the open circle.

Back to article page