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Figure 3 | Molecular Pain

Figure 3

From: Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa

Figure 3

Effect of the GluR5 agonist ATPA on sIPSCs in SG neurons. (A) Facilitatory effect of ATPA (3 μM) on sIPSCs in one SG neuron from wild-type mouse (left panel). Effect of ATPA (10 μM) on sIPSCs (top right trace) in one SG neuron from GluR5-/- mouse (right panel). (B) Inhibitory effect of GluR5 antagonist LY293558 (30 μM) on sIPSCs in one SG neuron from wild-type mouse (n = 9). * P < 0.05. (C) Effect of ATPA (3 μM) on GABAergic sIPSCs in the presence of strychnine (0.5 μM) (top trace) and glycinergic sIPSCs in the presence of bicuculline (10 μM) (bottom trace). (D) Pooled data of the effect of ATPA on sIPSC frequency from wild-type (n = 9) and GluR5-/- (n = 5) neurons. *** P < 0.001 compared with the control value. (E) Pooled data of the effect of ATPA on sIPSC amplitude from wild-type (n = 9) and GluR5-/- (n = 5) neurons.

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Molecular Pain

ISSN: 1744-8069

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