Figure 2
From: Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice
Global Na v 1.3 KO mice develop normally. (A) Weight (males P = 0.28 and females P = 0.80) and (B) performance on the rotarod (P = 0.21) were not different between the Nav1.3 KO (black) and WT (white). (C) Peak current density (nA/pF) of TTX-s current for small neurons (<25 μm) in WT = 0.097 ± 0.023 vs. KO = 0.156 ± 0.033 (n = 9 and 11, respectively; P = 0.16). TTX-r current (corresponding to Nav1.8) in WT = 0.065 ± 0.028 vs. KO = 0.115 ± 0.029 (P = 0.24). Peak current density of TTX-s current in medium neurons (>27 μm) in WT = 0.179 ± 0.69 vs. KO = 0.223 ± 0.055 (n = 5 and 6, respectively; P = 0.63). TTX-r current in WT = 0.071 ± 0.034 vs. KO = 0.118 ± 0.054 (P = 0.49).