Figure 4
From: Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice
Ectopic discharges is unchanged in Na v 1.3 KO mouse. Ectopic discharges in L5 (cut) and L4 (spared) sensory neurons following nerve injury are not different in the Nav1.3 KO global mouse (black). (A) An example trace from spontaneously active L5 fibres from Nav1.3 KO mouse. (B) Number of spontaneously active fibres in L5 is 3 times greater than that in L4 (L5 vs. L4 in WT P = 0.016 and in KO P = 0.016). Spontaneous activity is not different between KO and WT (P = 0.89 in L5 and P = 0.98 in L4, n = 6 mice in all groups). (C) Mean number of burst per minute in L5 is double that in L4 (L5 vs. L4 in WT P = 0.025 and in KO P = 0.022) but not different between KO and WT (P = 0.37 in L5 and P = 0.33 in L4). (D) Mean number of spikes per burst is not different between KO and WT (P = 0.58 in L5 and P = 0.61 in L4) and between L5 and L4 (WT P = 0.95 and in KO P = 0.58). (E) Mean burst length is not different between KO and WT (P = 0.63 in L5 and P = 0.96 in L4) and between L5 and L4 (WT P = 0.73 and in KO P = 0.56).