Figure 1
From: Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity
Na v 1.8-null mice display marked deficits in mechanically-evoked dorsal horn neuronal activity. (a) Wide dynamic range neurones recorded from Nav 1.8 -/- (n = 30) show significantly reduced activity to punctate mechanical von Frey stimuli compared to littermate control Nav 1.8 +/+ (n = 45) mice. Data is expressed as means + or - sem. *p < 0.05. (b) Example traces of two single neurones, one recorded from a Nav +/+ mouse and one from a Nav -/- mouse. Stimuli were applied for 10 s onto the peripheral receptive field of the neurone located on the hindpaw. In both groups a graded response is displayed to increasing stimulus intensity (brush, von Frey 1 – 75 g and pinch), but this is markedly reduced in Nav 1.8 -/- mice compared to Nav 1.8 +/+ mice.