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Figure 2 | Molecular Pain

Figure 2

From: Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity

Figure 2

Na v 1.8-null mice show no alteration in thermally-evoked dorsal horn neuronal activity. (a) Wide dynamic range neurones recorded from Nav 1.8 -/- (n = 30) show similar activity to thermal stimuli compared to littermate control Nav 1.8 +/+ (n = 45) mice. Data is expressed as means + or - sem. (b) Example traces of two single neurones, one recorded from a Nav +/+ mouse and one from a Nav -/- mouse. Thermal stimuli (water jet) were applied for 10 s onto the peripheral receptive field of the neurone located on the hindpaw. In both groups a graded response is displayed to increasing temperature and this is comparable in Nav 1.8 -/- and Nav 1.8 +/+ mice.

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