Figure 3
From: Nav 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity
Na v 1.8-null mice show altered neuronal activity to in a stimulus-dependent manner. (a) Wide dynamic range neurones recorded from Nav 1.8 -/- (n = 30) show significantly reduced activity to brush, noxious cold 1°C and noxious pinch stimuli compared to littermate control Nav 1.8 +/+ (n = 45) mice. Stimuli were applied to the peripheral receptive field of the neurone located on the hindpaw (b) Wide dynamic range neurones recorded from Nav 1.8 -/- (n = 30) and Nav 1.8 +/+ (n = 45) mice show no difference in responses evoked to transcutaneous electrical stimulation of the neuronal receptive field. Similar levels of neuronal activity evoked by A-fibres (A) and C-fibres (C), and related postdischarge (PD), input (INP) and wind-up (WU) measures were recorded (see methods for descriptions). Data is expressed as means + or - sem. *p < 0.05.