Figure 2
From: HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
Antinociceptive effect of S4IL4 in rats with neuropathic pain resulting from SNL. Filled diamonds – S4IL4; open squares – SHZ; open triangles – vehicle control. Mechanical allodynia is identical in vehicle control and SHZ-inoculated animals [21]. Values presented as mean ± SEM, n = 6–8 animals per group. Arrows indicate time of vector inoculation. X-axis: weeks after SNL. In each case, P < 0.01 comparing S4IL4-inoculated to control, using the general linear model (GLM) for repeated measures. (a) Mechanical allodynia in animals inoculated with vector 1 week after SNL. (b) Thermal hyperalgesia in animals inoculated with vector 1 week after SNL. (c) Mechanical allodynia in animals inoculated with the vector 1 week prior to SNL. (d) Thermal hyperalgesia in animals inoculated with the vector 1 week prior to SNL.