Figure 4From: Protein phosphatase 2A regulates central sensitization in the spinal cord of rats following intradermal injection of capsaicinEffects of two PP2A inhibitors, OA and fostriecin, on the reduced exploratory activity of rats initiated by capsaicin injection during a consecutive period of 45 minutes (9 intervals, 5 min/interval). Compared to the rats in the ACSF-pretreated group (n = 7), the rats with either OA (20 nM, n = 7) or fostriecin (30 nM, n = 5) pretreatment displayed significantly decreased exploratory activity, including a decreased number of photobeams broken (A), shortened distance traveled (B), decreased active time (C), increased resting time (D), shortened rearing time (E), and decreased number of rearing events (F). *p < 0.05.Back to article page