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Figure 4 | Molecular Pain

Figure 4

From: Protein phosphatase 2A regulates central sensitization in the spinal cord of rats following intradermal injection of capsaicin

Figure 4

Effects of two PP2A inhibitors, OA and fostriecin, on the reduced exploratory activity of rats initiated by capsaicin injection during a consecutive period of 45 minutes (9 intervals, 5 min/interval). Compared to the rats in the ACSF-pretreated group (n = 7), the rats with either OA (20 nM, n = 7) or fostriecin (30 nM, n = 5) pretreatment displayed significantly decreased exploratory activity, including a decreased number of photobeams broken (A), shortened distance traveled (B), decreased active time (C), increased resting time (D), shortened rearing time (E), and decreased number of rearing events (F). *p < 0.05.

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