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Figure 1 | Molecular Pain

Figure 1

From: Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization

Figure 1

The voltage dependent decrease in AP amplitude recorded from a small diameter, WT DRG neuron is best fit by 2 Boltzmann equations. APs were elicited by threshold stimulation while holding the cell membrane potential between -90 and -25 mV. Inset waveforms on the right represent responses elicited at the membrane holding potential indicated by the small letters (a-f). The dotted lines in the insets indicate 0 mV. The solid and dashed lines in the main figure represent Boltzmann equation fits with V1/2 values of -74.3 mV and -34.7 mV, respectively. For this cell, the contribution of the more hyperpolarized component accounted for 10% of the decrease in AP amplitude.

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Molecular Pain

ISSN: 1744-8069

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