Figure 5
The absence of Nav1.8 sodium channels alters the voltage dependent decrease in AP amplitude. Responses from a small DRG neuron cultured from a Nav1.8(-/-) mouse are shown as inset waveforms on the right (a-f). In these neurons, the decrease in AP amplitude as membrane holding potential is depolarized from -90 to -30 mV is best fit by a single Boltzmann equation (solid line in main figure). The V1/2 (-53.4 mV for this cell) is about 20 mV more depolarized than the TTX-s component in small DRG neurons from WT mice. The dotted lines in inset waveforms indicate 0 mV.