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Figure 6 | Molecular Pain

Figure 6

From: Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization

Figure 6

Transfection with Na v 1.8 produces two populations of cells with respect to voltage-dependence of AP amplitude. Data are from two small DRG neurons from Nav1.8(-/-) mice transfected with Nav1.8. The cell in (A) is representative of a population of cells (N = 7) for which the decrease in AP amplitude was best fit with single Boltzmann equation having a V1/2 of -53.9 mV (solid line). The cell in (B) is representative of a population of cells (N = 8) for which the decrease in AP amplitude was best fit by two Boltzmann equations, with V1/2 values of -72.6 mV (solid line) and -33.3 mV (dashed line).

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