Figure 2

Long-term potentiation (LTP) of sensory excitatory synapses in adult mouse spinal cord. A. Diagram of a spinal slice showing the placement of a whole-cell patch-clamp recording and a stimulation electrodes in the superficial dorsal horn of the adult mouse spinal cord. B. Schematic illustrating the induction protocol consisting 80 pulses at 2 Hz while holding at +30 mV (paired training). C. A example of spinal LTP induced by paired training protocol in a superficial dorsal horn neuron. D. Summary result of the LTP experiments under control conditions (n = 9 neurons). EPSC responses were averaged over five-minute intervals [Modified from 40].