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Figure 3 | Molecular Pain

Figure 3

From: Neuronal mechanism for neuropathic pain

Figure 3

Long-term potentiation of sensory excitatory synapses in adult mouse ACC. A. Current-clamp recordings to identify pyramidal neurons (upper) and interneurons (bottom) by current injections of -100, 0, and 100 pA. A labeled pyramid-like neuron was shown on the top right. RP: resting membrane potential. B. LTP was induced in pyramidal neurons (n = 15) in adult ACC by the pairing training protocol (indicated by an arrow). The insets show averages of 6 EPSCs 5 min before and 25 min after the pairing training (arrow). The dashed line indicates the mean basal synaptic responses. C. An example showing the long-lasting synaptic potentiation. Pairing training is indicated by an arrow. D. Basic synaptic transmission showing no change during recording without applying pairing training. The insets show averages of 6 EPSCs at the time points of 5 (pre) and 35 (post) min during the recording [Modified from 15].

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