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Figure 3 | Molecular Pain

Figure 3

From: Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity

Figure 3

Intrathecal injection of MK-801 or nifedipine inhibited the frequency-dependent activation of pERK in the spinal dorsal horn. MK-801 or nifedipine was injected into the intrathecal space 20 min before the electrical stimulations. A-C: Photomicrographs show pERK expression evoked by electrical stimulation at 0.5 Hz in the spinal cord of rats that received vehicle (A), MK801 (B) and nifedipine (Nifedi, C). Scale bar, 100 μm (in C for A-C). D-E: Quantification of pERK immunoreactivity in lamina I-II of ipsilateral spinal cord after electrical stimulation at the indicated frequencies in the MK-801 treated group (D) and nifedipine treated group (E) (n = 4 in each group, *p < 0.01 compared with vehicle). Open bars; vehicle treated group, filled bars; MK-801 or nifedipine treated group.

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Molecular Pain

ISSN: 1744-8069

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