Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?

Molecular Pain

Table 1 High-priority candidate polymorphisms that may affect motor control.

Gene*	Molecule	SNP	Location	AA change	Ref	Frequency		Function	Relation to Motor Control	Total
						%	No
DRD2/ANKK1	Ankyrin repeat and kinase domain 1	C32806T	3' region/Exon 8	Glu713 Lys	[42]	46	3	3	3	9
GCH1	GTP cyclohydrolase 1	C94A	Exon 1	Thr 94 Lys	[14]	15	2	3	3	8
GLRA1	Glycine receptor 1α	G1192A	Exon 6	Arg271 Glu	[43]	12	2	3	3	8
CACNA1S	Calcium channel, voltage-dependent, L type, α-1S subunit	T2403C	Exon 18	no	[44]	25	3	2	3	8
GABR1A	GABA A receptor 1 α	T156C	Exon 4	Lys278 Met	[45]	28	2	3	3	8
RyR1	Ryanodine receptor 1 gene	G6178T	Exon 38	Gly2060 Val	[46]	12	2	3	3	8
ADRA2C	Adrenergic receptor 2C	12 NT Ins/Del	Coding region/3rd intracellular loop	no	[47]	35	3	2	2	7
5HT2A	Serotonin 2A receptor	T102C	Exon 3	His 452 Tyr	[48]	9	1	3	3	7
GABBR1	GABAB receptor gene 1	G1465A	Exon 11	Gly489 Ser	[49]	10	2	2	2	6
ADRA2A	α2A adrenergic receptor	C1291G	Promoter region	no	[50]	26	2	2	2	6
5HT1A	Serotonin 1A receptor	C1019G	Promoter region	no	[51]	29	2	2	2	6
CNR1	Cannabinoid receptor gene 1	G1359A	Exon1	no	[52]	31	3	0	2	5
CHRM1	Human M1 muscarinic receptor	C1221T	Exon 6	C407	[53]	16	2	1	2	5
Rab3A	Rat brain associated protein 3A	C428T	Exon3	Val72 Met	[54]	26	2	1	2	5
SCN4a	Sodium channel receptor gene	A669G	Exon 12	Arg672 Cys	[55]	NA	0	2	3	5

*Genes listed in bold type were genotyped in this study, along with 5 intermediate-priority polymorphisms

ISSN: 1744-8069