Figure 5
From: Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain
TH-IR and pericellular baskets in injured and non-injured DRG neurons. A to D Representative photomicrograph of double fluorescent immunohistochemistry for ATF3 (green) and TH (red) in L4 DRG 8 weeks after SNI. A and B, TH-IR fibers surround both non-injured (arrow), and injured cells (arrowhead, ATF3 positive). Not all injured neurons (asterisks) are encircled by TH-IR fibers, scale bar 25 μm. C and D, TH-IR pericellular basket structures around non-injured (C) and injured (D) DRG neurons, scale bar 10 μm. E, Quantification of TH-IR pericellular basket in injured and non-injured DRG neurons in control and SNI groups (1, 4 and 8 weeks after surgery).