Figure 4
From: Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons
Forskolin and 8-Br-cAMP mimic PGE2-elicited increase in ATP currents. (A) Effects of forskolin. (Left) Examples of the action of forskolin (1 μM, 6 min) or PGE2 (1 μM, 2 min) on fast-inactivating ATP currents in the same cell. (Right) Forskolin and PGE2 potentiatied ATP currents (IATP (PGE2)/IATP = 1.45 ± 0.09; IATP (Forskolin)/IATP = 1.52 ± 0.10, n = 5). (B) 8-Br-cAMP enhanced ATP currents (IATP (PGE2)/IATP = 1.46 ± 0.08, IATP(8-Br-cAMP)/IATP = 1.55 ± 0.09, n = 4) (*P < 0.05). (C) Forskolin occludes the effect of PGE2. In the presence of foskolin, PGE2 could not further increase ATP currents.