Figure 1
From: Actions of N-arachidonyl-glycine in a rat inflammatory pain model
NA-glycine reduces mechanical allodynia. (a) Time plots of the effect of NA-glycine (NAGly,700 nmol, filled circles), HU-210 (10 nmol, filled squares), or vehicle (open circles) on mechanical paw withdrawal threshold (Mech PWT). Animals received an intrathecal injection of NA-glycine, HU-210 or a matched vehicle at time 0 h, 24 h after intraplantar injection of FCA. Data is also shown prior to FCA injection (Pre-FCA). (b) Bar charts depicting the effect of intrathecal injection of combinations of NA-glycine (NAGly 70 – 700 nmol), HU-210 (10 nmol), AM251 (30 nmol) and vehicle on mean mechanical paw withdrawal threshold, measured as the area-under-the-curve (AUC). * denotes P < 0.05, ** P < 0.01 and # P < 0.0001 compared to time 0 post-FCA in (a) and to vehicle in (b).