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Figure 1 | Molecular Pain

Figure 1

From: The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord

Figure 1

Effects of nicotine on spontaneous IPSCs in lamina V neurons. A, A continuous recording of sIPSCs in the control and following the application of nicotine (Nic, 100 μM). B, A histogram shows the time course of the changes in sIPSC frequency following the application of nicotine; time bin is 10 s. C, The graph shows the individual result from 9 lamina V neurons. D. Effects of mecamylamine (Mec) on nicotine-induced increase in sIPSC frequency. The consecutive traces on the left are sIPSCs in the control (upper panel) and following the application of nicotine (lower panel) in the presence of mecamylamine (5 μM). The consecutive traces on the right are sIPSCs in the control (upper panel) and following the application of nicotine (lower panel) after the washout of mecamylamine. Note that the bath application of nicotine did not affect the sIPSCs in the presence of mecamylamine, but it markedly increased sIPSC frequency after the washout of mecamylamine. E, Two histograms show time courses of changes in sIPSC frequency following the application of nicotine in the presence of mecamylamine (left) and after the washout of mecamylamine (right); time bin is 10 s.

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Molecular Pain

ISSN: 1744-8069

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