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Figure 2 | Molecular Pain

Figure 2

From: Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain

Figure 2

Nerve injury alters the sensory specificity of lamina I projection neurons. a. The majority (79%) of lamina I projection neurons in naïve rats were nociceptive specific whereas the majority (58%) of those recorded in nerve injured rats responded to both noxious and innocuous stimuli. The rate meter records show representative responses to natural stimuli (B = Brush; T = Touch; P = Pinch) of two identified lamina I projection neurons in a naïve rat and a rat with nerve injury. The inset shows the responses of the cells to trains of stimuli delivered in the parabrachial nucleus at decreasing interspike intervals; the cells followed > 500 Hz stimulation confirming antidromic activation (see methods and Fig. 1b). b. The cumulative probability plots show a significant increase in the response to innocuous (data from responses to brush and touch were pooled) and noxious (pinch) stimulation of the hind paw in lumbar spinal lamina I projection neurons after nerve injury. Results are expressed as total number of spikes during the stimulus for response to Brush/Touch and Pinch and throughout the duration of the afterdischarge (in other words, area under the curve).

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