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Figure 3 | Molecular Pain

Figure 3

From: Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain

Figure 3

Occurrence of spontaneous bursts of activity in lamina I projection neurons following nerve injury. Continuous records showing an example of an epoch with spontaneous bursts of activity occurring in lamina I projection neurons after nerve injury (6 out of 8 where ongoing activity was measured over a sufficiently long period to obtain a quantitative measure). The bursts were characterized by spikes arising on top of a slower wave, which contrasted with the evoked activity in response to touch (lower trace; arrowheads indicated touch stimuli). Such bursts were virtually absent in control animals even after several hours of recording. The insets on the right show examples of spontaneous and evoked activity on a faster time scale.

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Molecular Pain

ISSN: 1744-8069

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