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Figure 5 | Molecular Pain

Figure 5

From: Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain

Figure 5

Stimulated microglia or disruption of chloride homeostasis provoke the occurrence of spontaneous bursts of activity in lamina I projection neurons. Continuous records showing the appearance of spontaneous bursts of activity in lamina I projection neurons after local administration of ATP-stimulated microglia or DIOA. The bursts were comparable to those observed in lamina I neurons from nerve-injured rats (see Fig. 3). Such burst were virtually absent in control conditions even after several hours of recording. The insets on the right show example bursts on a faster time scale.

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Molecular Pain

ISSN: 1744-8069

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