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Figure 1 | Molecular Pain

Figure 1

From: Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice

Figure 1

Effect of targeted disruption of the nNOS gene on nerve injury-induced neuropathic pain. L5 spinal nerve injury produced a significant increase in paw withdrawal frequencies in response to 0.24 mN (low intensity) (A) and 4.33 mN (moderate intensity) (B) mechanical stimuli on the ipsilateral (ipsi) side in wildtype (WT) mice. The nNOS knockout (KO) mice displayed impaired mechanical pain hypersensitivity on the ipsilateral side (A, B). No significant changes in paw withdrawal frequencies were seen on the contralateral (contral) side after L5 spinal nerve injury in either WT or nNOS KO mice. **P < 0.01 vs corresponding time points in the WT mice.

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Molecular Pain

ISSN: 1744-8069

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