Skip to main content
Figure 1 | Molecular Pain

Figure 1

From: Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin

Figure 1

Changes in cutaneous blood flow and paw-thickness in the hindpaw of rats following ipsilateral intradermal (i.d.) injection of CAP in the hindpaw and the effects of dorsal rhizotomy (DRZ) and intrathecal bicucuclline (BICU). A and B: Samples of the laser Doppler flowmetry traces show changes in cutaneous blood flow in the rat hindpaw following CAP injection and the effects of dorsal rhizotomy. C and D: Mean results of blood flow and paw-thickness recordings summarizing the effects of DRZ and intrathecal BICU on the CAP-evoked inflammation. Blood flow pre-CAP injection was expressed as 100% (dashed line). Change in paw-thickness following CAP injection was presented as the difference score before and after CAP injection. Bicuculline (BICU) or ACSF was given intrathecally 20 min prior to CAP injection. Inset shows the sites where CAP was injected intradermally and blood flow was measured. *: P < 0.05, compared to the value in sham-dorsal rhizotomized or ACSP pretreated group.

Back to article page