Skip to main content
Figure 2 | Molecular Pain

Figure 2

From: Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice

Figure 2

A. On-going activity in C-fibers before (open bar) and after (filled bar) injection of simplified inflammatory soup into each fiber's mechanical receptive field was significantly increased in TRPV4+/+ (n = 11, paired t-test, * p < 0.05) but not TRPV4-/- mice (n = 13, paired t-test, p > 0.05). B. The mechanical threshold of C-fibers in TRPV4+/+ (open bar, n = 11) produced by intradermal injection of simplified inflammatory soup was statistically significant (Wilcoxon matched test, * p < 0.05). However, simplified inflammatory soup did not significantly change mechanical threshold of C-fibers in TRPV4-/- mice (filled bars, n = 13, Wilcoxon matched test, p > 0.05). The change in mechanical threshold of C-fibers after simplified inflammatory soup was significantly greater in TRPV4+/+ than TRPV4-/- C-fibers (χ2 test, * p < 0.05).

Back to article page