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Figure 1 | Molecular Pain

Figure 1

From: Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain

Figure 1

Histograms showing levels of NK-1 receptor and BDNF mRNA in the ipsilateral dorsal horn of the rat spinal cord 24 h, 4 days, 10 days and 21 days after a unilateral injection of complete Freund's adjuvant (s.c.) into the right hind paw. A) NK-1 receptor gene expression was significantly increased at 24 h and 4 days following CFA injection, with more robust response occurring at the earliest time point. At 10 and 21 days post CFA treatment NK-1 receptor mRNA levels were similar to sham controls. B) CFA treatments evoked increases in ipsilateral dorsal horn BDNF gene expression at all time points, with most robust up-regulation occurring at 21 days, following a triple CFA treatment. Data are expressed in pg mRNA/ng β-actin mRNA (Mean ± S.E.M.; n = 6); *p < 0.05 compared to the sham control group [ANOVA and Fisher's PLSD]; # < 0.05 compared to the CFA over 21 days (1×; single injection) [ANOVA and Fisher's PLSD].

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