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Figure 2 | Molecular Pain

Figure 2

From: Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain

Figure 2

Histograms showing NK-1 receptor and BDNF mRNA levels in the rat hippocampus 24 h, 4 days, and 21 days following a unilateral injection of complete Freund's adjuvant (s.c.) into the right hind paw. A) Hippocampal NK-1 receptor gene expression was significantly decreased bilaterally at all time points post CFA injection. The most robust decreases in NK-1 receptor mRNA levels occurred at 21 days after a triple CFA injection; significant difference was observed when compared to either the control group or a single CFA injection 21 days group. B) CFA evoked bilateral decreases in hippocampal BDNF mRNA levels at 24 h and 4 days post injection. Note that at 21 days, a single CFA treatment (1×) had no effect, while a triple injection (3×) induced a significant down-regulation of BDNF gene expression. Data are expressed in pg mRNA/ng β-actin mRNA (Mean ± S.E.M.; n = 6); *p < 0.05 compared to the sham control group [ANOVA and Fisher's PLSD]; #p < 0.05 compared to the CFA over 21 days (1×; single injection) [ANOVA and Fisher's PLSD].

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Molecular Pain

ISSN: 1744-8069

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