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Figure 4 | Molecular Pain

Figure 4

From: Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain

Figure 4

Histograms showing quantitative results of Western blot analysis for activation of ERK proteins 24 h (single injection) and 21 days (three injections) after a unilateral administration of complete Freund's adjuvant (s.c.) into the right hind paw. A) CFA had no effect no phosphorylation of ERK1 in either ipsilateral dorsal horn of the spinal cord or bilateral hippocampus. B) Hippocampal levels of p-ERK2 protein were not affected by the CFA treatment; however, in the dorsal horn CFA evoked a significant increase in p-ERK2 at both 24 h and 21 days after the administration. Optical density values are expressed as a ratio between the phosphorylated ERK (activated form) and total ERK (inactive form). Data are shown as % increase over sham control (n = 5); *p < 0.05 compared to control group (ANOVA and Student-Newman-Keuls' post-hoc test).

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Molecular Pain

ISSN: 1744-8069

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