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Figure 5 | Molecular Pain

Figure 5

From: Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain

Figure 5

Quantitative results of Western blot analysis showing the effects of CFA-evoked peripheral nociception on activation of CREB protein. CFA increased phosphorylation of CREB in the ipsilateral dorsal horn at 24 h (single injection) and 21 days (three injections) post administration. Note that in the hippocampus the same treatment produced an opposite effect; p-CREB levels were significantly reduced at all time points. Optical density values are expressed as a ratio between the p-CREB (activated form) and total CREB (inactive form). Data are shown as % increase over sham control (n = 5); *p < 0.05 compared to control group (ANOVA and Student-Newman-Keuls' post-hoc test).

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Molecular Pain

ISSN: 1744-8069

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