Figure 4
From: Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C
ET-1 also potentiates capsaicin-activated currents in HEK293 cells cotransfected with TRPV1 and the ET B R. A, Current responses to capsaicin (10 nM) application were potentiated by the application of ET-1 (100 nM). B, Bar graph summarizing the effects of ET-1 on normalized capsaicin responses in cells cotransfected with TRPV1-YFP and the ETBR. Shown are the first (n = 7, p = 0.0102) and second (n = 6, p = 0.0163) capsaicin response after ET-1 normalized to the capsaicin response before ET-1 application.