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Figure 5 | Molecular Pain

Figure 5

From: Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C

Figure 5

Potentiatory effects of forskolin and PMA onTRPV1. A, Adenylyl cyclase activation with forskolin (50 μM) resulted in a small increase in current responses to capsaicin (caps, 10 nM) whereas application of the PKC activator PMA (1 μM) resulted in a large potentiation of responses to capsaicin. B, Bar graph showing the control and the first two normalized responses to capsaicin after forskolin (forskolin 1: n = 5, p = 0.0271; forskolin 2: n = 4, p = 0.067) and PMA (PMA 1: n = 4, p = 0.0922; PMA 2: n = 4, p = 0.0088) application.

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