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Figure 6 | Molecular Pain

Figure 6

From: Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C

Figure 6

Protein kinase C inhibitors, but not protein kinase A inhibitors prevent the potentiation of TRPV1 by ET-1. A, Current trace from an experiment in which the PKC inhibitor BIM X (500 nM) was applied immediately prior to stimulation with ET-1 (100 nM) illustrating that BIM X treatment prevented potentiation by ET-1. B, Bar graph summarizing the effects of ET-1 on the first response to capsaicin after ET-1 in the absence (n = 6, p = 0.0156) and presence of BIM X (n = 7, p = 0.8964). C, Trace showing ET-1 potentiation of capsaicin-activated currents in the presence of the PKA inhibitor H-89. D, Bar graph summarizing the effects of ET-1 on the first (n = 4, p = 0.0953) and second (n = 4, p = 0.0275) capsaicin responses after treatment with H-89. Cells were cotransfected with TRPV1-YFP and the ETAR.

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