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Figure 7 | Molecular Pain

Figure 7

From: Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C

Figure 7

ET-1 does not potentiate capsaicin responses from the PKC phosphorylation site mutant TRPV1-S800A. A, top, Current trace showing responses to capsaicin (10 nM) before and after ET-1 (100 nM) application to a HEK293 cell cotransfected with TRPV1-S800A and the ETAR. Bottom, Current response to capsaicin after ET-1 in top trace on an expanded time scale. B, Bar graph summarizing the effects of ET-1 on the first (n = 4, p = 0.0735) and second (n = 4, p = 0.0921) capsaicin responses after ET-1 application recorded from TRPV1-S800A.

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