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Figure 3 | Molecular Pain

Figure 3

From: Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

Figure 3

LTP induced by TBS protocol is blocked by PD98059. A: A scheme illustrating the LTP induction protocol consisting of 5 trains of burst with 4 pulses at 100 Hz, 200 ms interval, which are repeated 4 times with the interval of 10 s. B: LTP is induced by the TBS protocol. The TBS protocol induced significant LTP in the ACC of adult mice (n = 8). C: LTP is blocked by addition of PD98059 (50 μM) in the intracellular solution. Traces show averages of six EPSCs at baseline response (pre) and 30 min (post) after the TBS protocol (arrow). The dashed line indicates the mean basal synaptic response. D: Summary of the effects of PD98059 (50 μM, n = 6) on LTP induced by the TBS protocol. * P < 0.05 compared to baseline.

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Molecular Pain

ISSN: 1744-8069

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