Table 1 Effects of trichloro(sulfanyl)ethyl benzamides on capsaicin activation of TRPV1, icilin-activated TRPM8, 2-APB-activated TRPV3 and 4α-PDD-induced TRPV4. The ability of compounds to inhibit channel activation was evaluated up to a maximum concentration of 5 μM.
Compound | hTRPV1 | hTRPM8 | hTRPV3 | hTRPV4 |
|---|---|---|---|---|
AMG9090 | >5 | 2.43 | >5 | >5 |
AMG5445 | ND | >5 | >5 | >5 |
AMG2504 | >5 | >5 | >5 | >5 |
AMG7160 | >5 | >5 | >5 | >5 |