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Figure 2 | Molecular Pain

Figure 2

From: Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation

Figure 2

pERK and NK1r following pinch. These confocal images show a pERK- and b NK1r-immunoreactivity in a parasagittal section of the left dorsal horn following pinch stimulation. a Many pERK-positive profiles are present in a band that corresponds to laminae I and IIo. In b, the cell body of a large NK1r-positive lamina III neuron is indicated with an asterisk, and one of its dorsal dendrites is shown with arrows. The dorsal half of this dendrite (dorsal to the middle arrow) shows internalisation of the NK1r. The cell body and dorsal dendrite of the neuron are weakly immunoreactive for pERK (a). Two other pERK-positive cells in lamina III are indicated with arrowheads. These are not NK1r-immunoreactive, but have dorsal dendrites that extend at least as far as lamina II. The open arrowheads point to the dendrite of a large NK1r-immunoreactive lamina I neuron that has internalised receptor (b) and pERK-immunostaining (a). Images are projections of 7 optical sections at 2 μm z-spacing. Scale bar = 50 μm.

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Molecular Pain

ISSN: 1744-8069

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