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Figure 4 | Molecular Pain

Figure 4

From: A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition

Figure 4

TRPA1 is involved in CFA-induced mechanical hyperalgesia. (A) AP18 reverses CFA-induced mechanical hyperalgseia in wildtype mice (n = 8). Red symbols represent the paws treated with CFA. 24 hours later, mechanical sensitivity was assayed again ("after CFA" timepoint), and the same paws were injected with either AP18 (red circles) or vehicle (red triangle). Mechanical sensitivity was again monitored during the next four hours. Blue symbols represent the control uninjected paws. (B) AP18 reverses mechanical hyperalgesia in wildtype (red) but not TRPA1-deficient (green) littermates (n = 12, females). Same protocol as (A), data from CFA- and AP18-injected paws shown. Arrows indicate time of AP18 (or vehicle) injections. ***p < 0.001, **p < 0.01, *p < 0.05, two-tailed Student's t-test.

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