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Figure 4 | Molecular Pain

Figure 4

From: Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents

Figure 4

Specific analgesic effects of nicotine in ChAT AS-ODN-pretreated mice in paw pressure and thermal paw withdrawal tests. (A, B) Thermal paw withdrawal test in naïve mice. Time-course of paw withdrawal latency (s) after nicotine (10 nmol, 20 nmol and 30 nmol i.t.) injection (A). Comparison of analgesia (in AUC) following nicotine injection (B). (C, D) Paw pressure test. Time-course of paw withdrawal threshold (g) after nicotine (10 nmol i.t.) injection (C). Comparison of analgesia (in AUC) following nicotine injection (D). (C, D) Thermal paw withdrawal test. Time-course of paw withdrawal latency (s) after nicotine (10 nmol i.t.) injection (E). Comparison of analgesia (in AUC) following nicotine injection (F). *p < 0.05 vs. vehicle. Data represent the means ± S.E.M. from experiments using at least 6 mice.

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