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Figure 5 | Molecular Pain

Figure 5

From: Activation of the neurokinin-1 receptor by substance P triggers the release of substance P from cultured adult rat dorsal root ganglion neurons

Figure 5

Characteristics of the GR73632-evoked SP release from cultured adult rat DRG neurons. Some cells were left untreated as a control, all other cells were treated with GR73632 alone or together with three MAP kinases cascades inhibitors (10 μM U0126, 15 μM SB203580 and 30 μM SP600125), PLC inhibitor (10 μM U73122) or with COX inhibitors (1 μM NS-398 and 1 μM indomethacin), PKC inhibitors (1 μM Gö6976, 1 μM bisindolymaleimide, 200 μM PKCε translocation inhibitor peptide) or with PKA inhibitor (10 μM H89) in DMEM (serum free) for 60 min. The data are expressed as the means ± S.E.M. (bars) from 3–5 (A), 6 (B) or 4 (C), 4 (D) separate experiments. *, ** and *** denote p < 0.05, 0.01 and 0.001, respectively.

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Molecular Pain

ISSN: 1744-8069

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