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Figure 4 | Molecular Pain

Figure 4

From: Mechanically-evoked C-fiber activity in painful alcohol and AIDS therapy neuropathy in the rat

Figure 4

The ISI distributions of both EtOH (n = 15) group of C-fibers in responses to sustained (60 sec) threshold and 10 g stimuli were significantly changed. A&D, the ISI distributions of control C-fibers (n = 38) in responses to sustained threshold and 10 g stimuli, respectively. B&C, ISI 0.1–0.2 s of responses in EtOH group was significantly higher than that of controls (p < 0.05, t-test) and ISI 0.3–0.4 s of responses in ddC group (n = 18) was significantly higher than that of controls (p < 0.05, t-test). E&F, the ISI distributions of EtOH group in responses to 10 g stimulation were significantly changed while the ISI distributions of ddC group were similar to those of controls. ISI 0–0.2 s of responses in EtOH group was significantly higher than those of control animals (p < 0.01, t-test)

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