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Table 1 Electrophysiological properties of wild-type and I136V mutant NaV1.7 channels.

From: Mutation I136V alters electrophysiological properties of the NaV1.7 channel in a family with onset of erythromelalgia in the second decade

Channel

Activation

Fast Inactivation

Slow Inactivation

Ramp Current

 

V1/2,act

Slope

n

V1/2,inact

Slope

n

V1/2,inact

Slope

Rin

n

% of Imax

Vpeak

n

NaV1.7R

23.1 ± 0.7

6.40 ± 0.14

40

82.5 ± 1.3

6.94 ± 0.15

15

-66.0 ± 1.6

13.6 ± 0.3

0.19 ± 0.02

11

0.23 ± 0.02

-42.3 ± 0.9

19

I136V

28.8 ± 0.5*

7.13 ± 0.10*

43

79.7 ± 0.6

6.00 ± 0.27*

13

-74.0 ± 0.9*

8.7 ± 0.2*

0.11 ± 0.01*

11

0.79 ± 0.04*

-48.0 ± 0.5*

26

  1. *p < 0.05, I136V vs NaV1.7R.