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Figure 2 | Molecular Pain

Figure 2

From: Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: Implications for chemical-induced peripheral sensory neuropathies

Figure 2

The density of CD31+ vessels is site dependent within the mouse lumbar dorsal root ganglia (DRG). Representative 3D reconstructed confocal images of L4 DRG whole mount preparation from thy1-YFP transgenic mice where the cell body and axons of sensory neurons constitutively express yellow fluorescent protein (YFP, pseudocolored violet). In contrast, the endothelial cells were immunohistochemically labeled with a marker of platelet endothelial cell adhesion molecule, CD31+ (green) (A, B). Note that a dense vascular plexus surrounds sensory neuron cell bodies within cell body-rich areas (C), whereas the nerve fiber-rich areas have a lower density of CD31+ vascular labeling (D). The confocal image in A-D were acquired at 0.5 μm z-plane intervals and the total z-plane for (A) 90 μm, (B) 60 μm and (C&D) 15 μm. Scale bar A-D = 50 μm.

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Molecular Pain

ISSN: 1744-8069

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