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Figure 1 | Molecular Pain

Figure 1

From: Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo

Figure 1

LTP in the spinal dorsal horn is induced by LFS of C-fibres in the sciatic nerve. Electrical LFS at C-fibre strength delivered to the sciatic nerve induced LTP of C-fibre evoked field potentials in laminae I/II of the spinal cord dorsal horn, lasting undiminished for several hours. A representative example of LFS-induced LTP and two original recordings prior to (1) or after LTP-induction (2) are shown in (A). Areas of C-fibre evoked field potentials were used to quantify synaptic strength (dashed areas in 1 and 2). Mean time course of five experiments is shown in (B). In both graphs, area of C-fibre evoked field potentials (% of control) is plotted against time (min). The arrows represent the time point of conditioning LFS.

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